Chromatin immunoprecipitation definition

Chromatin immunoprecipitation (ChIP) is a type of immunoprecipitation used to investigate the interaction between proteins and DNA in the cell. It aims to determine whether specific proteins are associated with specific genomic regions, such as transcription factors on promoters or other DNA binding sites.

In order to select specific proteins bound to DNA, this technique requires the use of specific antibodies that will allow the isolation of the target protein-DNA complex.