| Flat bottom | Compatible with all microplate devices, such as washer and readers. Allows for excellent optical transmission and low background adsorbance. |
| Round bottom | Eliminates surface related steric hindrance associated with large molecule bounds in the corners. Efficient removal of liquid. Not recommended for biomolecules that are sensitive to the denaturing effects of excessive drying. |
| Ease edge bottom | Hybrid of flat and round bottom. The sharp bottom is eliminated. Allows for minimal retention of fluid, so that the negative effects of excessive drying are tolerable. |