EMT in cancer

Epithelial-Mesenchymal transtion (EMT) is one of the most important causes of cancer malignancy and it is related to cancer progression and metastasis (Figure 1).

Figure 1. Scheme of cancer malignancy due to EMT.

In addition to the phenotypic changes triggered by EMT in cancer cells, EMT also confer these cells a way to avoid cell cycle regulation events such as apoptosis, anoikis, and cellular senescence.