Genomic instability

Genomic instability occurs when chromosome integrity and function become compromised. This can take many forms; some examples include double or single strand breaks in chromosomes, mutations within the DNA sequence, fusions between chromosomes, and changes to telomere length.

Genome instability is a critical initiator of many diseases, including cardiovascular and neurodegenerative diseases, and cancers.

Dietary factors are essential in many of the processes that copy, repair and maintain healthy DNA throughout our lives.

References:

• Bull, C., & Fenech, M. (2008). Genome-health nutrigenomics and nutrigenetics: Nutritional requirements or ‘nutriomes’ for chromosomal stability and telomere maintenance at the individual level. Proceedings of the Nutrition Society, 67(02), 146-156. doi:10.1017/s0029665108006988