Mammalian cells, primarily Chinese hamster ovary (CHO), are often used as an expression system for synthesis of protein that needs post-translation modification, such as glycosylation. The following table summarizes the advantages and disadvantages of mammalian cells as an expression system.
|Capable of post-translation modification, including phosphorylation and glycosylation||Expensive|
|Protein produced is properly folded||Poor secretion|
Figure 1. Mammalian expression system.