Membrane potential

A voltage potential is a value representing the difference in electrical potential between two points. A membrane potential is the difference in electrical potential (in mV) between the outside and inside of a cell's membrane, on the intracellular side of the membrane based on the outside being zero.

Different types of cells have different resting membrane potentials. The resting membrane potential of neurons is -70 mV. During action potentials, the membrane potential changes drastically.

A membrane is made up of 2 layers of surfactant molecules. A surfactant molecule has a circular head and a wiggly tail. The surfactant heads point outwards and the surfactant tails point inwards. One side of the membrane is positively charged and is facing extracellular fluid. The other side of the membrane is negatively charged and is facing the cytosol. Attached to a  voltmeter are a reference electrode and a recording microelectrode. The reference electrode is placed on the positively charged surface of the membrane. The recording microelectrode is placed through the membrane so the electrode touches the positively charged surface and the negatively charged surface. The voltmeter reads a voltage of minus 70 millivolts.

Figure 1. Cell resting membrane potential