Comparison of polymer types
Alginate
Advantage
- biocompatibility
- 3D matrix for differentiated chondrocyte function
Disadvantage
- does not degrade rapidly in vivo
- loses integrity over time
- is difficult to control gelation rate
- its molecular weight distribution is less controlled
Typical cross-links
Typical application
- wound healing
- drug delivery
- cell encapsulation
Hyaluronic acid/ Hyaluronan
Advantage
- supports embryonic stem cell differentiation, proliferation, survival
- provides stability to the extracellular matrix molecules
- easily degraded by enzymes e.g. hyaluronidase
Disadvantage
- fast degradation
- its molecular weight distribution is less controlled
Typical cross-links
- photocrosslinking (when modified)
Typical application
- drug delivery
- joint disorders
- viscosupplementation
PEG
Advantage
- biocompatibility
- support survival of chondrocytes
- uniform distribution
Disadvantage
- limits cell proliferation
- has no innate biological cues
- has high permeability that can lead to diffusion of matrix away from the cells and out of the hydrogel
Typical cross-links
- michael addition, photocrosslinking
Typical application
- drug delivery
- cell encapsulation
- antifouling surfaces