Transglutaminases
Transglutaminases are a wide family of thiol enzymes that catalyze the formation of a covalent bond between free amine groups of lysine and the γ-carboxamide group of glutamine. The bonds formed by transglutaminase exhibit high resistance to proteolytic degradation. Transglutaminase (factor XIIIa) is involved in blood clotting by catalyzing the formation of fibrin.
Transglutaminase is Ca2+ dependent enzyme. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor.
